Terms of Use
GRADE Evidence Profile
Developer: Jithin T Joseph
Last updated: September 28, 2026
Purpose
GRADE Evidence Profile is a research-support tool intended to assist researchers, clinicians, students, reviewers, and evidence-synthesis teams with certainty-of-evidence assessment using GRADE methodology.
By using the plugin, you agree to these Terms of Use.
Research-support tool
GRADE Evidence Profile is intended to support, not replace, human methodological judgment.
Outputs should be independently checked by appropriately qualified reviewers before use in systematic reviews, meta-analyses, guidelines, publications, regulatory submissions, grant applications, or other consequential work.
Where duplicate independent appraisal is required by a protocol, use of this plugin does not constitute a second independent human reviewer.
No medical advice
The plugin performs research-methodology and evidence-synthesis tasks. It does not provide individualized medical diagnosis, treatment, or clinical management advice.
GRADE methodology
The plugin may assist with outcome-level judgments involving risk of bias, inconsistency, indirectness, imprecision, publication bias, and upgrading considerations where applicable.
It is designed to support structured judgment rather than apply rigid automatic scoring rules.
Users remain responsible for confirming that the correct GRADE framework, decision thresholds, and current official guidance are applied to their review question.
Independent status
GRADE Evidence Profile is independently developed and is not affiliated with, sponsored by, approved by, or endorsed by the GRADE Working Group or GRADEpro.
Users should consult current official GRADE guidance when conducting definitive assessments.
Source-grounded assessment
The quality of an assessment depends on the information available to the plugin. Users should provide sufficient outcome-level information and relevant methodological context.
The plugin may identify uncertainty where information is missing, inaccessible, inconsistent, or insufficiently reported.
No arbitrary numerical quality scores
GRADE certainty should be expressed using the standard categories High, Moderate, Low, or Very Low, rather than an invented numerical quality score.
Accuracy and limitations
AI-generated outputs can contain errors, including:
- inappropriate GRADE domain judgments;
- incorrect interpretation of decision thresholds;
- incomplete consideration of risk of bias;
- over- or under-downgrading;
- missed upgrading considerations;
- inaccurate footnotes; or
- incomplete interpretation of the underlying evidence.
Users should verify consequential judgments against the source evidence and current official guidance.
Intellectual property
Users are responsible for ensuring lawful access to and use of materials they provide to the plugin.
References to GRADE terminology and methodology are descriptive and do not imply ownership or endorsement by the GRADE Working Group.
Prohibited use
Users should not use GRADE Evidence Profile to:
- fabricate evidence or methodological justifications;
- misrepresent an AI-generated assessment as an independent human review;
- create fraudulent research records;
- circumvent copyright or access restrictions; or
- misrepresent the plugin as an official GRADE Working Group or GRADEpro product.
Availability and changes
The plugin may be updated, modified, suspended, or discontinued as methodology and platform capabilities evolve.
Disclaimer
The plugin is provided as a research-support resource without a guarantee that every output will be complete, accurate, or suitable for a particular purpose.
Users retain responsibility for their research methodology, interpretations, publications, and decisions based on plugin outputs.
Contact
Questions, methodological feedback, suspected errors, or concerns can be submitted through the Support page.